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Boey® Neuromodulator: A Fast-Acting, Short-Duration Wrinkle Treatment

A new type of injectable wrinkle treatment could soon give patients greater flexibility when considering neuromodulators.

Boey® (trenibotulinumtoxinE) is a botulinum neurotoxin serotype E developed by Allergan Aesthetics, an AbbVie company. Unlike traditional neuromodulators designed to last several months, Boey® has been developed to provide a rapid onset with a shorter duration of effect.

Boey® is not currently approved or available in the United States. Wilmington Dermatology Center is closely following its regulatory progress and the evolving research behind this new treatment.

What Is Boey®?

Boey® is an injectable neuromodulator intended to temporarily improve the appearance of moderate-to-severe glabellar lines—the vertical lines between the eyebrows commonly called frown lines or “11 lines.”

Its active ingredient, trenibotulinumtoxinE, is derived from botulinum toxin serotype E. It works by temporarily blocking the release of acetylcholine at targeted neuromuscular junctions. This reduces contraction of the treated facial muscles and softens the appearance of expression lines.

Boey® is distinguished by two primary characteristics:

  • Rapid onset of effect
  • Shorter duration compared with conventional neuromodulators
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Designed for Fast-Acting, Short-Duration Results

In pivotal clinical studies reported by Allergan Aesthetics, some patients experienced the onset of Boey® results as early as eight hours after treatment.

The appearance of treated glabellar lines generally returned to baseline approximately two to three weeks after administration.

This shorter treatment window could appeal to patients who:

  • Are considering a neuromodulator for the first time
  • Want to experience a temporary preview of wrinkle-relaxing results
  • Prefer a shorter commitment before choosing a longer-lasting treatment
  • Have an upcoming event and want a fast-acting option
  • Are uncertain about how neuromodulator treatment will affect their appearance

Results, onset, duration and suitability may vary by patient.

What Areas Does Boey® Treat?

Boey® has been studied and approved for the temporary improvement of moderate-to-severe glabellar lines in adults.

These are the vertical lines that appear between the eyebrows when frowning.

Add a brief visual or labeled treatment-area graphic highlighting:

  • Glabellar lines
  • Frown lines
  • “11 lines”
  • Muscles between and slightly above the eyebrows

Make it clear that additional treatment areas have not been established or approved based on the information currently available.

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Boey® May Offer a “Preview” of Neuromodulator Results

One of Boey®’s most interesting potential applications is giving patients an opportunity to experience neuromodulator treatment without committing to results that may last three to four months—or longer.

Because Boey® has demonstrated a duration of approximately two to three weeks in clinical studies, it may provide an introductory option for appropriately selected patients who want to see how they look and feel with softened frown lines.

According to research cited by Allergan Aesthetics:

  • 80% of surveyed consumers were open to learning about new aesthetic treatments
  • 79% wished they could temporarily preview the outcome of an aesthetic treatment

Boey® could eventually help address that interest by offering a shorter-duration introduction to neuromodulator treatment.

Boey® vs. BOTOX® Cosmetic

Include a comparison table:

Feature Boey® BOTOX® Cosmetic
Active toxin type Botulinum toxin serotype E Botulinum toxin serotype A
Intended benefit Temporary improvement of glabellar lines Temporary improvement of approved facial lines
Reported onset As early as eight hours in Boey® studies Varies by patient and treatment area
Expected duration Approximately two to three weeks in pivotal studies Commonly lasts several months
Potential role Short-term experience or treatment preview Established, longer-lasting neuromodulator treatment
U.S. status Not currently FDA-approved FDA-approved for specific cosmetic indications

Follow the table with this key clarification:

Boey® is not intended to be described as a replacement for BOTOX® Cosmetic. The treatments have meaningfully different duration profiles and may serve different patient goals. BOTOX® Cosmetic is currently the only neurotoxin identified by Allergan Aesthetics as having been clinically evaluated for use following treatment with Boey®.

Boey® Approval and Regulatory Status

United States Availability

Boey® is not currently FDA-approved or available for cosmetic treatment in the United States. Its approval in Canada and positive European regulatory opinion do not authorize its use in the U.S.

Wilmington Dermatology Center will continue monitoring official regulatory developments.

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What Are the Possible Side Effects of Boey®?

According to the European Medicines Agency’s summary of its positive opinion, the most commonly reported side effects include:

  • Eyelid ptosis, or temporary eyelid drooping
  • Brow ptosis, or temporary lowering of the eyebrow
  • Mephisto sign, or unintended elevation of the outer eyebrow

Other risks may be identified in the official prescribing information applicable to each country.

If Boey® becomes FDA-approved, treatment should only be provided by a properly qualified medical professional with experience in facial anatomy, injectable treatments and the management of potential complications.

Why Choose Wilmington Dermatology Center for Neuromodulators?

When considering any injectable treatment—especially a newly introduced product—provider training and experience matter.
Wilmington Dermatology Center is recognized as a leading destination for cosmetic injectables in Wilmington and throughout coastal North Carolina. Dr. Rosalyn George is a national BOTOX® trainer and has been involved in clinical trials for innovative neuromodulator treatments, including the Boey® trials in the US.

WDC offers:

  • Extensive experience with cosmetic neuromodulators
  • Natural-looking, personalized treatment plans
  • Advanced knowledge of facial anatomy
  • A physician-led, safety-first approach
  • Access to established injectable options
  • Free cosmetic consultations
  • Ongoing involvement in cosmetic dermatology research
  • Recognition among the top 1% of BOTOX® practices nationally

Boey® Is Not Yet Available at WDC

Boey® is not currently available at Wilmington Dermatology Center because it has not been approved by the U.S. Food and Drug Administration.

Patients interested in treating frown lines, forehead lines or crow’s feet can schedule a free cosmetic consultation to learn about currently available neuromodulators, including:

  • BOTOX® Cosmetic
  • Dysport®
  • Daxxify®
  • Jeuveau®
  • Xeomin®

The WDC team can recommend an option based on the patient’s treatment goals, desired onset, preferred duration, facial anatomy and previous injectable experience.

Boey® Frequently Asked Questions

What is Boey®?

Boey® is a botulinum neurotoxin serotype E injectable developed for the temporary improvement of moderate-to-severe lines between the eyebrows.

How quickly does Boey® work?

In pivotal studies, some patients experienced an onset of effect as early as eight hours after injection.

How long do Boey® results last?

Clinical study information indicates that treated glabellar lines generally returned to baseline within approximately two to three weeks.

Is Boey® the same as BOTOX®?

No. Boey® uses botulinum toxin serotype E, while BOTOX® Cosmetic uses botulinum toxin serotype A. Boey® is designed to have a much shorter duration of effect.

Is Boey® approved in the United States?

No. Boey® is not currently FDA-approved or available for cosmetic treatment in the United States.

Can Boey® help me preview BOTOX® results?

Its short duration may eventually make Boey® an option for patients who want a temporary introduction to neuromodulator treatment. However, the two products are different, and Boey® results would not guarantee an identical response to BOTOX® Cosmetic.

Can I join a Boey® waiting list?

Patients may contact WDC to express interest in future treatment updates. Availability will depend on FDA approval and WDC’s clinical evaluation of the product.

What can I use while Boey® is unavailable?

WDC currently offers established neuromodulators such as BOTOX® Cosmetic, Dysport®, Daxxify®, Jeuveau® and Xeomin®. A consultation can help determine which option best matches your goals.

Serving Wilmington and Coastal North Carolina

Wilmington Dermatology Center serves patients seeking advanced cosmetic injectable treatments in Wilmington, Wrightsville Beach, Hampstead, Carolina Beach and surrounding communities throughout southeastern North Carolina.

Patients interested in Boey® updates or currently available wrinkle-relaxing treatments are encouraged to schedule a free cosmetic consultation.

Recommended Compliance Disclaimer

Boey® is not approved by the U.S. Food and Drug Administration and is not currently available at Wilmington Dermatology Center. Information on this page is provided for general educational purposes and should not be interpreted as an offer of treatment, medical advice or a guarantee of future availability. Regulatory status, indications, safety information and product availability may change.

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